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GraysGrays Dermatology

Melasma, Freckles, Seborrheic Keratoses, and Lentigines: Telling Them Apart and Choosing a Laser

2026-08-11 · Reviewed by the medical director (review date to be posted)

The short answer

Though they may look similar, melasma, freckles and seborrheic keratoses, lentigines, and nevus of Ota are distinct diagnoses that differ in depth and character. Identifying the lesion comes first and choosing the laser second — and above all, melasma is not a lesion to blast away but one to lighten and manage over time. That principle is the starting point of any treatment plan.

What kind of lesion is my pigment?

Freckles and seborrheic keratoses are epidermal lesions with relatively clear borders, and they tend to respond well to spot laser treatment. Melasma has blurred borders, spreads diffusely, and reacts sensitively to irritation — so it is managed with low-energy toning alongside lifestyle care (sun exposure, hormonal factors). Deep dermal pigment such as nevus of Ota requires a long-term plan with a high-power laser.

Why can't melasma be removed aggressively?

In melasma the melanocytes are in an overactive state, so excessive thermal stimulation can worsen the pigment or trigger rebound hyperpigmentation. That is why we manage it in multiple low-energy sessions, and decide on adjunct medication such as tranexamic acid based on the diagnosis.

Which devices does Grays use for pigment?

We use PicoWay (picosecond), StarWalker MaQX, QX MAX (nanosecond), and GentleMax Pro (long-pulse), matched to lesion depth and character. The reason we keep several devices is that each lesion calls for a different wavelength and pulse.

Pigmented lesions: characteristics and approach

LesionDepthCharacteristicsApproach
Freckles / seborrheic keratosesEpidermisClear bordersSpot removal, a few sessions
MelasmaEpidermis to dermal junctionBlurred borders, sensitive to irritationLow-energy toning + ongoing care
LentiginesEpidermisSmall, dark maculesSpot removal
Nevus of OtaDermisBluish tone, broad distributionLong-term high-power laser plan

Related treatments

Sources

  1. 01A Systematic Review of Picosecond Laser in Dermatology: Evidence and RecommendationsLasers Surg Med · 2021 · PubMed 32282094
  2. 02Efficacy and safety of picosecond laser for the treatment of melasma: a systematic review and meta-analysisLasers Med Sci · 2023 · PubMed 36897459
  3. 03PicoWay Laser System 510(k) clearanceUS FDA 510(k) Premarket Notification · 2017 · US FDA 510(k) K170597

These are the general references used for this guide. They do not warrant the results of treatment at this clinic.

This guide is general medical information and does not replace an individual diagnosis. Please seek an in-person consultation for decisions about your own care.

Consultation

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